Leukotrienes: Underappreciated Mediators of Innate Immune Responses

Of Innate Immune Responses Leukotrienes: Underappreciated Mediators

Exosomes: Mediators of Immune Regulation

Extracellular Vesicles, including exosomes, are small membrane fragments released from many cell types, like Mesenchymal Stem Cells (MSCs). They were recognized as a mechanism of intercellular communication. They can transfer proteins, lipids and nucleic acids to other cells. Thus, they have many physiological (angiogenesis, coagulation and tissue repair, etc.) and pathological (e.g. in autoimm...

HCV Innate Immune Responses

Hepatitis C virus (HCV) establishes a persistent infection in more than 70% of infected individuals. This striking ability to evade the powerful innate immune system results from viral interference occurring at several levels of the interferon (IFN) system. There is strong evidence from cell culture experiments that HCV can inhibit the induction of IFNβ by cleaving important proteins in the vir...

Innate Immune Responses during Sepsis

Alum Induces Innate Immune Responses